What is Sildenafil Citrate in 5 minutes

While everybody knows about Viagra, little understand how it works. This article will describe the way of action of this drug, as well as other Sildenafil-based drugs (Revatio, Caverta).

Sildenafil citrate is a synthetic PDE5 inhibitor. PDE-5 stands for phosphodiesterase enzyme. All processes in our body are controlled by chemical signals – so-called enzymes. PDE-5 is responsible for shortening the smooth muscles of the blood vessels and lowering the blood flow. Sildenafil citrate inhibits this enzyme secretion and forces smooth muscles of the blood vessels to relax, increasing the diameter of arteries and increasing blood flow.

This effect has 2 major applications:


  • When backed up by sexual stimulation it helps men with erectile dysfunction to get and maintain a steady erection for several hours
  • When taken regularly, sildenafil saturates the muscle tissues in lungs, relaxing them and lowering the blood pressure. This is used to treat PAH – Pulmonary Arterial Hypertension (tensed arteries increase blood pressure in lungs, leading to permanent chest pain, heart pain and short breath)

Sildenafil is a clear synthetic drug which is easily broken in kidneys after the end of intended action (for Viagra) and removed from the body with urine and feces. It causes no addiction or withdrawal effects.

However, Sildenafil is a quite potent drug and can cause multiple side effects if used unwisely. It can interact with many other drugs, potentially leading to many unpleasant consequences. Overdosing is not recommended due to possibility of lowering blood pressure too much, leading to fatal outcome.

First of all, thorough medical examination is needed in order to determine whether your body is able to take sildenafil and has no allergy to it. Then your doctor should be informed of all the drugs you permanently take to exclude possible drug interactions.

Sildenafil should not be used if you are taking nitrates, if you recently had a heart attack or have hereditary cardiovascular diseases. It is not recommended to pregnant or nursing women and is prohibited for children. Ask your health care specialist for more details. Using Viagra and Revatio at the same time is strictly prohibited due to the reasons mentioned above.

After all, Sildenafil is a potent tool allowing solving 2 big problems: it treats erectile dysfunction and helps fighting PAH. Use it correctly and you will live a healthy life, and happy life!